کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334918 546715 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment
چکیده انگلیسی


• Cortisol concentration is associated with brain structure in early psychosis.
• Over time, patients showed a reduction in thickness of posterior cingulate compared to controls.
• In patients, greater baseline cortisol predicted greater hippocampal volume increase over time.

Stress and abnormal hypothalamic–pituitary–adrenal axis functioning have been implicated in the early phase of psychosis and may partly explain reported changes in brain structure. This study used magnetic resonance imaging to investigate whether biological measures of stress were related to brain structure at baseline and to structural changes over the first 12 weeks of treatment in first episode patients (n=22) compared with matched healthy controls (n=22). At baseline, no significant group differences in biological measures of stress, cortical thickness or hippocampal volume were observed, but a significantly stronger relationship between baseline levels of cortisol and smaller white matter volumes of the cuneus and anterior cingulate was found in patients compared with controls. Over the first 12 weeks of treatment, patients showed a significant reduction in thickness of the posterior cingulate compared with controls. Patients also showed a significant positive relationship between baseline cortisol and increases in hippocampal volume over time, suggestive of brain swelling in association with psychotic exacerbation, while no such relationship was observed in controls. The current findings provide some support for the involvement of stress mechanisms in the pathophysiology of early psychosis, but the changes are subtle and warrant further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 231, Issue 2, 28 February 2015, Pages 111–119
نویسندگان
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