کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334936 546718 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased left hemisphere impairment in high-functioning autism: A tract based spatial statistics study
ترجمه فارسی عنوان
افزایش اختلال نیمکره چپ در مبتلایان به اوتیسم بالا: مطالعه آمار آماری فضایی مبتنی بر تراکم
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• We used diffusion tensor imaging to compare participants with autism to controls.
• Participants with autism demonstrate greater white matter impairment.
• The autism group had greater impairment in left compared to right hemisphere.
• Left hemisphere impairment in autism was attributable to myelination anomalies.

There is evidence emerging from Diffusion Tensor Imaging (DTI) research that autism spectrum disorders (ASD) are associated with greater impairment in the left hemisphere. Although this has been quantified with volumetric region of interest analyses, it has yet to be tested with white matter integrity analysis. In the present study, tract based spatial statistics was used to contrast white matter integrity of 12 participants with high-functioning autism or Aspergers syndrome (HFA/AS) with 12 typically developing individuals. Fractional Anisotropy (FA) was examined, in addition to axial, radial and mean diffusivity (AD, RD and MD). In the left hemisphere, participants with HFA/AS demonstrated significantly reduced FA in predominantly thalamic and fronto-parietal pathways and increased RD. Symmetry analyses confirmed that in the HFA/AS group, WM disturbance was significantly greater in the left compared to right hemisphere. These findings contribute to a growing body of literature suggestive of reduced FA in ASD, and provide preliminary evidence for RD impairments in the left hemisphere.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 224, Issue 2, 30 November 2014, Pages 119–123
نویسندگان
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