کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3349779 1216364 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance
چکیده انگلیسی

BackgroundAltered cytokine production can lead to immune dysfunction in cancer patients. Hence, we investigated the cytokine balance in oral squamous cell carcinoma (OSCC) patients and their significance in providing new therapeutic insights.MethodsWe quantified Th17 (IL17A), Treg (TGFβ1), Th1 (IL2, IFNγ) and Th2 (IL4, IL10) like cytokines in the sera of 78 cases and 39 controls by ELISA. The intracellular expression of these cytokines was analyzed in 10 subjects from each group by flow cytometry.ResultsSerum levels of IL17A, TGFβ1, IL4 and IL10 were significantly higher while IL2 and IFNγ were relatively lower in patients as compared to controls. TGFβ1 (r = 0.55), IL4 (r = 0.75) and IL10 (r = 0.80) significantly (P < 0.0001) correlated with disease progression and their elevated levels showed increased odd ratios of approximately 18, 14 and 37, respectively. IL17A appeared as a risk factor (OR = 2.21, 95% CI = 0.89–5.42) although statistically insignificant. The levels neither correlated with disease progression nor with TGFβ1, IL4 and IL10 but showed positive association with IL2 (r = 0.51, P < 0.0001) and IFNγ (r = 0.24). Flow cytometry data also showed similar trend.ConclusionsWe reported a distinct TGFβ1 and Th2 (IL4, IL10) polarization with a borderline elevation of IL17A while, a suppression of Th1 (IL2, IFNγ) cytokines in OSCC patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 75, Issue 4, April 2014, Pages 330–337
نویسندگان
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