Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

ObjectiveWe explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA).MethodsWe performed a meta-analysis on the association between the four gene polymorphisms and RA.ResultsNineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR = 1.057, 95% CI = 0.782–1.429, p = 0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR = 1.294, 95% CI = 1.063–1.576, p = 0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR = 1.363, 95% CI = 1.126–1.651, p = 0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR = 1.366, 95% CI = 1.093–1.707, p = 0.006) and in Asians (OR = 1.402, 95% CI = 1.059–1.855, p = 0.014).ConclusionsOur meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.