کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3350200 | 1591377 | 2015 | 5 صفحه PDF | دانلود رایگان |
The HLA-DR and -DQ loci are close neighbors on chromosome 6 that are highly linked. Many common associations between HLA-DR and DQ-alleles are known, normally transmitted as HLA-DR̃DQ haplotypes from one generation to another. Reports of very recent genetic rearrangements between HLA-DR and -DQ are rarely found in the literature. In Europeans haplotypes containing DRB1∗15:01, DQB1∗02:01, and DQA1∗05:01 have not been reported before. We report the finding of the rare HLA haplotype A∗24:02̃C∗07:02̃B∗07:02̃MICA∗008:01̃DRB5∗01:01̃DRB1∗15:01̃DQA1∗05:01̃DQB1∗02:01̃DPB1∗04:01 in a German stem cell donor with East Frisian ancestry. Our observation suggests a rare ancestral recombination between the DR and DQ loci. In order to investigate this haplotype, we typed 50/74 members of the family encompassing four generations for HLA classes I and II by serological and molecular methods. The rare haplotype was identified in 12 heterozygous carriers. Furthermore, we identified and further characterized a putative crossing over event resulting in its reversion to a common haplotype.
Journal: Human Immunology - Volume 76, Issues 2–3, March 2015, Pages 124–128