کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3350779 1216406 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computer-aided human leukocyte antigen association studies: A case study for psoriasis and severe alopecia areata
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Computer-aided human leukocyte antigen association studies: A case study for psoriasis and severe alopecia areata
چکیده انگلیسی

We present an integer programming model for human leukocyte antigen (HLA) association studies based on the parsimony criterion. The model is simple, compact, easy to implement, and able to handle datasets containing up to 200 phenotypes. Computational experiments carried out on patients affected by psoriasis and severe alopecia areata show that the model is consistent with the experimental haplotype frequencies, showing, for the considered diseases at least, a high reliability of the predictions. These promising results provide perspective on computer-aided association studies and encourage the development of efficient exact computational approaches for haplotype estimation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 71, Issue 8, August 2010, Pages 783–788
نویسندگان
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