کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3352043 1216453 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of the cellular immune response in patients with the digestive and indeterminate forms of Chagas' disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Analysis of the cellular immune response in patients with the digestive and indeterminate forms of Chagas' disease
چکیده انگلیسی

SummaryThe commitment of the digestive organs observed in patients during the chronic phase of Chagas' disease is mainly attributed to neuronal damage induced by immune and inflammatory processes elicited by the presence of Trypanosoma cruzi. Here we compare the cellular immune response in patients with the digestive and indeterminate forms of Chagas' disease on the basis of lymphocyte proliferation and cytokine production after antigen or mitogen stimulation. No significant differences between patients groups were observed on proliferative response or on tumor necrosis factor (TNF)-α and interleukin (IL)-10 levels, although IL-10 achieves higher levels than TNF-α after T. cruzi antigen stimulation. Interferon (IFN)-γ basal production was significantly higher in the digestive form and IL-4 was significantly higher in patients with megaesophagus when compared with patients with megacolon. These results indicated that patients with the digestive form of Chagas' disease do not suffer immune suppression and that the cytokine balance favors a strong inflammatory reaction in patients with the digestive form, which may contribute to lesions of the mioenteric nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 69, Issue 8, August 2008, Pages 484–489
نویسندگان
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