کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3352095 1591380 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association Analysis of MYO9B Gene Polymorphisms with Celiac Disease in a Swedish/Norwegian Cohort
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Association Analysis of MYO9B Gene Polymorphisms with Celiac Disease in a Swedish/Norwegian Cohort
چکیده انگلیسی

Association between myosin IXB (MYO9B) gene variants and celiac disease (CD) has been reported in a study of a Dutch cohort. Six single nucleotide polymorphisms (SNPs) within the 3′ part of the MYO9B gene showed significant genetic association and formed an associated haplotype. The current study aimed to replicate these findings in a Swedish/Norwegian cohort. Genotyping of the three SNPs which tagged the associated haplotype was performed in a CD family dataset (n = 326) and in an additional set of healthy controls (n = 562). Although our material provided reasonable power to detect the previously observed association, we were unable to replicate association with these SNPs. Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. Alternatively, it might be due to variable linkage disequilibria in distinct populations in the tested SNPs and a causative mutation yet to be identified or to false positive findings (type I error) in the Dutch study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 67, Issues 4–5, April–May 2006, Pages 341–345
نویسندگان
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