کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3352305 1216470 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD8+ regulatory T cells in persistent human viral infections
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CD8+ regulatory T cells in persistent human viral infections
چکیده انگلیسی

Regulatory T cells (Treg cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), and herpes virus. It has recently become evident that immune regulation mediated by Treg cells may comprise one mechanism that contributes to the impairment of virus-specific immune responses. Indeed, during viral infection, the generation of distinct subsets of CD4+ as well as CD8+ Treg cells has been reported. The phenotypic and functional heterogeneity of Treg cell subsets involved in the suppression of virus-specific immune responses suggests that different mechanisms and factors contribute to the generation of those cells during viral infection. This review focuses on the CD8+ Treg cell subset and summarizes current knowledge about the induction and function of CD8+ Treg cells in persistent human virus infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 69, Issue 11, November 2008, Pages 771–775
نویسندگان
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