کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335270 546903 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Self-reported social functioning and prefrontal hemodynamic responses during a cognitive task in schizophrenia
ترجمه فارسی عنوان
عملکرد اجتماعی خود گزارش شده و پاسخ های همودینامیک پیش فونتال در طول یک وظیفه شناختی در اسکیزوفرنیا
کلمات کلیدی
جنون جوانی، طیف سنجی نزدیک به مادون قرمز، وظیفه روانی کلامی، عملکرد پیش فرنتن، عملکرد اجتماعی خود گزارش شده
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Prefrontal hemodynamic responses and social functioning in schizophrenia was studied.
• Hemodynamic responses measured by near-infrared spectroscopy during verbal fluency task.
• Social functioning assessed using Social Functioning Scale (SFS).
• Prefrontal cortical activation is associated with the SFS total score.
• NIRS might prove to be a useful biological marker for social functioning in schizophrenia.

Impaired social functioning is a characteristic of schizophrenia that affects patients’ quality of life. The aim of the study was to assess prefrontal hemodynamic responses during a cognitive task and establish its influence on psychiatric symptoms, cognitive function, global functioning, and self-reported social functioning in patients with schizophrenia. Thirty-three patients with schizophrenia and 30 age-and sex-matched healthy controls participated in the study. We measured hemodynamic responses in the prefrontal and superior temporal cortical surface areas with 52-channel near-infrared spectroscopy (NIRS) during a verbal fluency task (VFT). Self-reported social functioning was assessed using the Social Functioning Scale (SFS). Regional hemodynamic responses were significantly smaller in the prefrontal and temporal regions in subjects with schizophrenia than in the controls, and prefrontal hemodynamic responses during the VFT showed a strong correlation with SFS total scores. These results suggest an association between self-reported social functioning and prefrontal activation in subjects with schizophrenia. The present study provides evidence that NIRS imaging could be helpful in understanding the neural basis of social functioning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 234, Issue 1, 30 October 2015, Pages 121–129
نویسندگان
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