کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
335523 546983 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased left striatal dopamine transmission in unaffected siblings of schizophrenia patients in response to acute metabolic stress
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Increased left striatal dopamine transmission in unaffected siblings of schizophrenia patients in response to acute metabolic stress
چکیده انگلیسی

A genetic alteration in sensitivity to stress, mediated by mesolimbic hyperdopaminergia, is thought to play a role in the onset, exacerbation and relapse of schizophrenia. Dopamine sensitivity to stress was tested in individuals at higher than average genetic risk for schizophrenia (siblings of patients). Using a PET paradigm of [11C]raclopride in a bolus plus constant infusion tracer injection, the central DA response to acute metabolic stress (bolus of 2-Deoxy-d-Glucose, 40 mg/kg) in unaffected siblings of patients with schizophrenia (n = 8) and healthy controls (n = 10) was measured by BPND of [11C]raclopride before and after the 2DG challenge. After metabolic stress, controls but not siblings displayed a significant decrease in BPND of [11C]raclopride in the striatum; no such differences were apparent in the ventral striatum. Siblings but not controls displayed significant asymmetry (L > R) in the stress-induced DA release, especially in ventral striatum, which correlated strongly with psychometric measures of psychosis liability. The results suggest that asymmetry in the mesolimbic DA response to stress is associated with genetic risk for schizophrenia, possibly reflecting the functional consequences of structural disconnectivity underlying psychotic symptoms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 181, Issue 2, 28 February 2010, Pages 130–135
نویسندگان
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