STAT4 rs7574865 polymorphism in Iranian patients with rheumatoid arthritis

Although most studies have proposed STAT4 polymorphisms as a susceptible risk factor for RA, we did not detect any significant association between the STAT4 polymorphism and RA in our study. Population-based studies help to identify genetic determinants of disease susceptibility. Possible explanations for differences in susceptible genetic factors among populations could be different genetic predispositions and contribution of gene-gene or gene-environment interactions.