کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3358377 | 1591750 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics and safety/tolerability of higher oral and intravenous doses of rifampicin in adult tuberculous meningitis patients
ترجمه فارسی عنوان
فارماکوکینتیک و ایمنی / تحمل بالای دوزهای خوراکی و داخل وریدی ریفامپینسین در بیماران مبتلا به مننژیت باکره بالغ
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کلمات کلیدی
مننژیت خفیف، ریفامپیسین، فارماکوکینتیک، تحمل پذیری، اندونزی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
High-dose intravenous (i.v.) rifampicin improved the outcome of tuberculous meningitis (TBM) in a previous study. Unfortunately, i.v. rifampicin is not available in many high-endemic settings. This study examined exposures to and safety of higher oral rifampicin doses compared with i.v. rifampicin. Thirty adult Indonesian TBM patients were randomised to rifampicin 750âmg (ca. 17âmg/kg) orally, 900âmg (ca. 20âmg/kg) orally or 600âmg (ca. 13âmg/kg, as used previously) i.v. over 1.5âh for 14 days, combined with other TB drugs. The pharmacokinetics of rifampicin was assessed in the critical phase of TBM treatment (â¤3 days after treatment initiation) and at â¥9 days. In the first days of treatment, the geometric mean (range) plasma AUC0-24 values following rifampicin 750âmg orally, 900âmg orally and 600âmg i.v. were 131.4 (38.1-275.1), 164.8 (66.9-291.2) and 145.7 (77.7-430.2) mgâ
h/L, respectively; Cmax values were 14.3 (6.1-22.2), 16.2 (5.7-28.3) and 24.7 (13.9-37.8) mg/L. CSF concentrations correlated with plasma exposures. After â¥9 days, AUC0-24 values had decreased to 100.1, 101.2 and 94.9âmgâ
h/L. Transient grade 3 ALT increases (8/30 patients) and one grade 4 ALT increase occurred, not related to rifampicin exposure. Higher oral rifampicin doses resulted in approximately similar plasma AUC0-24 but lower plasma Cmax values compared with 600âmg i.v. over 1.5âh. Exposures to rifampicin varied substantially and decreased due to autoinduction. Liver function disturbances occurred in this severely ill population. Future studies should examine even higher rifampicin doses in TBM treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 48, Issue 4, October 2016, Pages 415-421
Journal: International Journal of Antimicrobial Agents - Volume 48, Issue 4, October 2016, Pages 415-421
نویسندگان
Vycke Yunivita, Sofiati Dian, Ahmad Rizal Ganiem, Ela Hayati, Tri Hanggono Achmad, Atu Purnama Dewi, Marga Teulen, Petra Meijerhof-Jager, Reinout van Crevel, Rob Aarnoutse, Rovina Ruslami,