کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3358974 | 1591788 | 2013 | 6 صفحه PDF | دانلود رایگان |
The clinical implications of free linezolid monitoring have not been fully clarified in critically ill patients. The aim of this study was to evaluate the variability in pharmacokinetics of free linezolid and its relationship with susceptibility to meticillin-resistant Staphylococcus aureus (MRSA) in critically ill patients. Twenty critically ill MRSA-infected patients receiving intravenous linezolid were enrolled. Blood specimens were collected by 12-h sampling after dosing at Day 7. The medians (interquartile range) of the minimum free concentration, area under the concentration–time curve of total and free linezolid from 0 to 24 h (AUC0–24 and fAUC0–24, respectively) and percentage bound were 9.9 μg/mL (5.2–15 μg/mL), 495 μg h/mL (291–695 μg h/mL), 385 μg h/mL (242–528 μg h/mL) and 23% (15–28%), respectively. The medians of the AUC0–24 and fAUC0–24 to minimum inhibitory concentration ratios (AUC/MIC and fAUC/MIC) were 248 (144–347) and 192 (109–264), respectively. Two patients failed to achieve adequate levels of AUC/MIC and fAUC/MIC for linezolid. The percentage bound of linezolid in hypoalbuminaemic patients was significantly lower than in non-hypoalbuminaemic patients. A significant correlation was observed between fAUC0–24 and creatinine clearance. In addition, the fAUC0–24 was correlated with the minimum free concentration. In conclusion, the plasma level of free linezolid was variable in critically ill patients with renal dysfunction and hypoalbuminaemia. This finding suggests that the monitoring of free linezolid is necessary in critically ill patients.
Journal: International Journal of Antimicrobial Agents - Volume 42, Issue 4, October 2013, Pages 329–334