Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: A voxel-based morphometry study

We sought to investigate the link between substance abuse and increased striatal gray matter densities (GMD) in schizophrenia, using voxel-based morphometry (VBM). Increased striatal GMD were found in patients with schizophrenia and substance use disorder (n = 12), but not schizophrenia only patients (n = 11), compared to healthy volunteers (n = 15).