کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3359491 | 1591829 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance—antibiotic DU90% profiles with bacterial resistance rates: a visual presentation Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance—antibiotic DU90% profiles with bacterial resistance rates: a visual presentation](/preview/png/3359491.png)
High use of amoxicillin/clavulanic acid (AMC) at the University Hospital Osijek (Croatia) contributed to high rates of resistance in Enterobacteriaceae, in particular Escherichia coli (50%). Thus, in order to decrease bacterial resistance, AMC use was restricted. We present results of the restriction on resistance amongst antibiotics accounting for 90% of antibiotic use [drug utilisation 90% (DU90%)]. Data were analysed on antibiotic use and microbiological susceptibility of E. coli during two 9-month periods, before and after the restriction of AMC use. Drug use was presented as numbers of defined daily doses (DDDs) and DDDs/100 bed-days. Resistance of E. coli to antibiotics was presented as percentages of isolated strains in the DU90% segment. Use of AMC was 16 DDDs/100 bed-days or 30% of all antibiotics before the intervention. Use of AMC fell to 2 DDDs/100 bed-days or 4% after the intervention, and resistance of E. coli fell from 37% to 11%. In conclusion, restricted use of AMC resulted in a significant decrease of E. coli resistance. DU90% resistance profiles are simple and useful tools in highlighting problems in antibiotic use and resistance but may also be useful in long-term follow-up of antibiotic policy.
Journal: International Journal of Antimicrobial Agents - Volume 36, Issue 4, October 2010, Pages 369–373