کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3359693 | 1591835 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Leishmaniasis vaccines: past, present and future Leishmaniasis vaccines: past, present and future](/preview/png/3359693.png)
No vaccine exists against any form of leishmaniasis. Because recovery from infection is usually accompanied by a strong immunity and because it is possible to protect experimental animals against live challenge, hope for the development of a vaccine for humans has been high. However, leishmaniasis is a disease of the poor and the market for a vaccine is very limited. Until a few years ago, with minimal resources, only a pragmatic approach was possible for testing the first-generation vaccines (i.e. killed whole parasites). Recently, funding has become available for developing defined second-generation vaccines, including recombinant proteins and DNA constructs. With new adjuvants also being developed there is new hope, and several new vaccines are in development against leishmaniasis.
Journal: International Journal of Antimicrobial Agents - Volume 36, Supplement 1, November 2010, Pages S58–S61