کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3360787 | 1591879 | 2007 | 6 صفحه PDF | دانلود رایگان |
In this study, we explored risk factors associated with bacteraemia caused by colistin-susceptible/carbapenem-resistant (CoS/CaR) Acinetobacter baumannii. A retrospective cohort study of hospitalised patients with A. baumannii bacteraemia was performed at a tertiary care hospital over a 44-month period. Thirty-nine patients with bacteraemia due to A. baumannii (35 Intensive Care Unit and 4 ward patients) were included in the analysis. Twenty-five patients (64%) had bacteraemia due to CoS/CaRA. baumannii and 14 patients (36%) had bacteraemia due to colistin-susceptible/carbapenem-susceptible A. baumannii. Mortality was 56% (14/25) and 35.7% (5/14) for patients in the two groups, respectively (P = 0.22). Bivariate analysis showed that prior exposure to fluoroquinolones (P = 0.01) and antipseudomonal penicillins (P = 0.004) as well as a higher number of antibiotics in use on the day of bacteraemia (P = 0.02) were associated with isolation of a CoS/CaR strain among patients with A. baumannii bacteraemia. Multivariate analysis using a backward logistic regression model showed that only exposure to fluoroquinolones was associated with development of CoS/CaRA. baumannii bacteraemia (odds ratio = 11.6; 95% confidence interval 2.4–55.9; P = 0.02). The appearance of CoS/CaRA. baumannii infections represents a major threat to critically ill hospitalised patients. Exposure to fluoroquinolones is an independent risk factor for development of CoS/CaRA. baumannii bacteraemia.
Journal: International Journal of Antimicrobial Agents - Volume 30, Issue 5, November 2007, Pages 409–414