کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
336207 547088 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prereproductive stress in adolescent female rats affects behavior and corticosterone levels in second-generation offspring
ترجمه فارسی عنوان
استرس قبل از تولد در موش های صحرایی نوجوان، رفتار و سطح کورتیکوسترون در فرزندان نسل دوم را تحت تاثیر قرار می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• We ask whether prereproductive stress (PRS) to female rats affects F2 progeny.
• PRS in adolescence led to reduced anxiety and enhanced fear learning in F2.
• PRS also led to sex-dependent changes in corticosterone across three generations.
• Stress leads to adaptive behavior in second-generation progeny.
• Adolescent stress transgenerationally affects behavior and neuroendocrine function.

SummaryHuman and animal studies indicate that vulnerability to stress may be heritable. We have previously shown that chronic, mild prereproductive stress (PRS) in adolescent female rats affects behavior and corticotropin releasing factor 1 (CRF1) expression in the brain of first-generation (F1) offspring. Here, we investigated the effects of PRS on anxiogenic behavior and CRF1 expression in male and female second-generation (F2) offspring. Furthermore, we assessed levels of the stress hormone corticosterone (CORT), a direct marker of hypothalamic–pituitary–adrenal (HPA) axis function, in PRS females and their F1 and F2 progeny. F2 offspring demonstrated decreased CRF1 mRNA expression at birth, and alterations in anxiogenic behavior in adulthood. CORT levels were elevated in PRS females and in their F1 female, but not male, offspring. In F2, CORT levels in PRS offspring also varied in a sex-dependent manner. These findings indicate that PRS in adolescent females leads to behavioral alterations that extend to second-generation offspring, and has transgenerational effects on endocrine function. Together with our previous findings, these data indicate that PRS to adolescent females affects behavior and HPA axis function across three generations, and highlight the importance of examining the transgenerational effects of stress in both male and female offspring.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 58, August 2015, Pages 120–129
نویسندگان
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