کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3362260 | 1592059 | 2015 | 8 صفحه PDF | دانلود رایگان |
• An outbreak of 61 joint and cutaneous infections due to M. massiliense occurred at a single clinic.
• All cases were injected with triamcinolone, and frequent injection was associated with infection.
• The outbreak could have been due to a contaminated environment in the preparation of the injection.
• Repeated injection of triamcinolone may have made patients prone to infection.
• Education on safe corticosteroid injection processes and infection control is needed.
SummaryObjectivesAn outbreak of joint and cutaneous infections among patients who had been injected at a single clinic in South Korea was investigated.MethodsIn this retrospective case–control study, 61 cases were diagnosed based on symptoms and signs of septic arthritis or cutaneous infection that developed after injections at the clinic between April and September 2012; 64 controls were investigated by administering questionnaires on risk factors and analyzing the clinic medical records. An environmental investigation was performed, and clinical specimens of the cases were analyzed by pulsed-field gel electrophoresis.ResultsAll cases were injected with triamcinolone. A greater number of triamcinolone injections (adjusted odds ratio 4.3, 95% confidence interval 1.5–12.1 for six or more visits, compared with one or two visits) was associated with the development of an infection. In the clinic, only the triamcinolone injection was prepared by mixing with lidocaine and normal saline, and an alcohol swab was prepared using boiled tap water by members of the clinic staff. Although injected medications and environmental cultures were not found to be responsible, a single strain of Mycobacterium massiliense was isolated from the affected sites of 16 cases.ConclusionsRepeated injection of triamcinolone contaminated with NTM from the clinic environment may have caused this post-injection outbreak.
Journal: International Journal of Infectious Diseases - Volume 36, July 2015, Pages 62–69