کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3364719 1592144 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in Western Turkey
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in Western Turkey
چکیده انگلیسی

SummaryObjectiveThe primary aim of this study was to determine the recent distribution of various genotypes of hepatitis C virus (HCV) in patients with chronic HCV infection in Western Turkey. Additional objectives were to determine whether there are any associations of genotype with gender and age, and to determine the nucleotide similarities and risk factors of non-1 HCV genotypes.MethodsSerum samples from 345 patients (176 male, 169 female; mean age 53.3 ± 12.7 years, range 10–81 years) with chronic HCV infection were analyzed in this study. Viral genotypes were determined by a restriction fragment length polymorphism (RFLP)-based in-house assay. To confirm genotypes for the samples with band patterns other than genotype 1, the 5′ UTR was amplified and sequenced.ResultsGenotype 1 was observed in 335 of the 345 patients (97.1%). Of these, 34 patients showed infection with subtype 1a (9.9%) and 301 with subtype 1b (87.2%). Genotypes 2, 3, and 4 were determined in 0.9%, 1.4%, and 0.6% of the patients, respectively. Patients infected with type 1 were significantly older than patients infected with non-1 genotypes; however no significant differences were recorded in gender distribution.ConclusionsGenotypes other than genotype 1 are quite rare; these are possibly acquired in other countries. Turkish patients with chronic hepatitis C still represent a rather homogenous group with genotypic diversity encountered rarely.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Infectious Diseases - Volume 12, Issue 3, May 2008, Pages 239–244
نویسندگان
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