کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3366864 | 1218420 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role for interleukin-6Â in structural joint damage and systemic bone loss in rheumatoid arthritis
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
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چکیده انگلیسی
Interleukin-6 (IL-6) plays a key role in the local and systemic manifestations of rheumatoid arthritis (RA). IL-6Â is not only a proinflammatory cytokine, but also interacts in complex ways with the cells involved in bone remodeling. In RA, IL-6Â may indirectly promote osteoclastogenesis by increasing the release of RANK-L by osteoblasts and synovial cells. However, IL-6Â inhibits osteoclastogenesis in vitro, via a direct mechanism. The effects of IL-6Â on osteoblasts may vary with the cell differentiation stage: thus, IL-6Â may promote the differentiation of pre-osteoblasts to mature osteoblasts while also diminishing the proliferation of osteoblasts at late differentiation stages. Thus, the effects of IL-6Â on bone remodeling are complex and may occur in opposite directions depending on the model or experimental conditions. Nevertheless, results from studies in animal models and humans support a negative effect of IL-6Â on bone. Thus, in patients with RA, blocking IL-6Â may be effective both in diminishing the inflammatory manifestations and in preventing the bone complications of the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 77, Issue 3, May 2010, Pages 201-205
Journal: Joint Bone Spine - Volume 77, Issue 3, May 2010, Pages 201-205
نویسندگان
Benoit Le Goff, Frédéric Blanchard, Jean-Marie Berthelot, Dominique Heymann, Yves Maugars,