کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3366953 | 1218423 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy](/preview/png/3366953.png)
IntroductionWe report on our experience with 13 cases of jaw osteonecrosis in patients treated with amino-bisphosphonates.MethodData were collected by a regional observatory for jaw osteonecrosis in northern France via letters sent to all physicians likely to manage patients with this condition. All study patients were evaluated at a multidisciplinary jaw osteonecrosis clinic between June and December 2005.ResultsWe identified 13 cases, in 12 women and 1 man, with a mean age of 62.6 years. Intravenous amino-bisphosphonate therapy was given for metastatic bone disease from breast cancer in 7 patients and multiple myeloma in 5 patients; the remaining patient was on oral alendronate for osteoporosis. Mean treatment duration was 24 months. A history of dental extraction was found in 11 (84.6%) patients. The mandible was involved in all 13 patients and the maxillary in 3 (23%) patients. Amino-bisphosphonate therapy was discontinued in all 13 patients. We suggest a classification scheme for the clinical and computed-tomography patterns seen in our patients.ConclusionJaw osteonecrosis is a severe complication of amino-bisphosphonate therapy. In addition to the application of published guidelines, we propose discontinuing bisphosphonate therapy whenever possible. We are evaluating our classification scheme to identify early diagnostic criteria and/or clinical and computed-tomography outcome criteria that would improve the management of patients with jaw osteonecrosis.
Journal: Joint Bone Spine - Volume 75, Issue 1, January 2008, Pages 34–40