کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
336759 547208 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Function and modulation of δ-containing GABAA receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Function and modulation of δ-containing GABAA receptors
چکیده انگلیسی

Summaryαβδ-Containing GABAA receptors are (1) localized to extra- and perisynaptic membranes, (2) exhibit a high sensitivity to GABA, (3) show little desensitization, and (4) are believed to be one of the primary mediators of tonic inhibition in the central nervous system. This type of signaling appears to play a key role in controlling cell excitability. This review article briefly summarizes recent knowledge on tonic GABA-mediated inhibition. We will also consider the mechanism of action of many clinically important drugs such as anxiolytics, anticonvulsants, and sedative/hypnotics and their effects on δ-containing GABA receptor activation. We will conclude that αβδ-containing GABAA receptors exhibit a relatively low efficacy that can be potentiated by endogenous modulators and anxiolytic agents. This scenario enables these particular GABA receptor combinations, upon neurosteroid exposure for example, to impart a profound effect on excitability in the central nervous system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 34, Supplement 1, December 2009, Pages S67–S73
نویسندگان
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