کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3367601 1218463 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiovascular disease in rheumatoid arthritis: Single-center hospital-based cohort study in France
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Cardiovascular disease in rheumatoid arthritis: Single-center hospital-based cohort study in France
چکیده انگلیسی

IntroductionRheumatoid arthritis (RA) was independently associated with cardiovascular events in several studies, most of which were conducted in the US.ObjectivesTo estimate the risk of cardiovascular events in a cohort of RA patients recruited at a hospital in France, to identify cardiovascular risk factors, and to measure the severity of cardiovascular events.MethodsTwo hundred and thirty-nine patients admitted between January 1, 1998, and March 31, 1999, for RA meeting American College of Rheumatology criteria, with a negative history for cardiovascular events, were sent a questionnaire in 2004 to evaluate the occurrence of myocardial infarction, stroke, or cardiovascular death.ResultsDuring the mean follow-up of 5.4 ± 1.8 years, there were 10 cases of myocardial infarction (0.8%/year), 3 cases of stroke (0.2%/year), and 9 cardiovascular deaths (0.7%/year). Of the 10 patients who experienced myocardial infarction, 5 had clinical symptoms of heart failure and 4 died from cardiovascular causes. Independent risk factors for cardiovascular events were older age (relative risk [RR], 2.5/10 years; 95% confidence interval [95%CI], 1.4–4.2), male gender (RR, 5.1; 95%CI, 1.8–14.6), treated hypertension (RR, 4.3; 95%CI, 1.4–13.2), and treated hypercholesterolemia (RR, 6.0; 95%CI, 1.8–20.7).ConclusionOur data suggest a higher risk of cardiovascular events in patients with RA compared to the general population in France (0.1–0.5%/year for myocardial infarction and 0.07%/year for stroke in the age group covered by our cohort). Cardiovascular events in the patients with RA seemed unusually severe. Patients with RA should be carefully screened for conventional cardiovascular risk factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 74, Issue 1, January 2007, Pages 66–72
نویسندگان
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