کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3369538 1219040 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Survey for the presence of BK, JC, KI, WU and Merkel cell polyomaviruses in human brain tissues
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Survey for the presence of BK, JC, KI, WU and Merkel cell polyomaviruses in human brain tissues
چکیده انگلیسی

BackgroundRecently three previously unknown polyomaviruses (KI, WU and Merkel cell polyomaviruses) have been identified from human specimens. The spectrum of clinical manifestations and their tissue tropism are currently unknown. Since a member of this virus family, JC virus, is well-known for its capacity to establish latency in human brain tissue where reactivation in immunocompromised individuals can result in fatal progressive multifocal leukoencephalopathy, we sought to examine for the presence of all the five known human polyomaviruses in a series of human brain tissues.ObjectivesTo investigate the possibility of neuropersistence of the newly identified human polyomaviruses.Study designAutopsy brain tissues were collected from 10 different brain regions of 30 individuals who died from diseases unrelated to viral infections. Nested PCR was used to assess the presence or absence of viral DNA.ResultsTen samples collected from five individuals were found to harbour JCV DNA. In contrast, none of the 300 brain tissues examined showed positive results for BK, KI, WU or Merkel cell polyomavirus.ConclusionThe newly identified KI, WU and Merkel cell polyomaviruses either do not, or have a much lower neuropersistent potential compared to JCV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 48, Issue 1, May 2010, Pages 11–14
نویسندگان
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