کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3371017 | 1219100 | 2007 | 5 صفحه PDF | دانلود رایگان |

Background and objectiveHepatitis C virus (HCV) infection is frequent in HIV-positive subjects. We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs).Study designWe studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the follow-up (late progressors; LPs).ResultsHCV coinfection was detected in 19/26 LTNPs and 15/23 LPs. Univariate analysis showed that HIV viral load was associated with disease progression (P = 0.04), and time-to-event analysis indicated that HCV genotype 1 significantly correlated with LTNP status (P = 0.031). At multivariate analysis, HIV viremia at study entry remained independently associated with LTNP status (P = 0.049). When the most represented genotypes (1 and 3a) were considered in the model, genotype 3a infection (P = 0.034) and gender (P = 0.035) emerged as independent variables related to HIV disease progression, whereas HIV viral load disappeared.ConclusionsIn addition to HIV viremia, coinfection with different HCV genotypes and gender may affect LTNP status.
Journal: Journal of Clinical Virology - Volume 39, Issue 2, June 2007, Pages 82–86