کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3371017 1219100 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors: Possible protective effect of infecting HCV genotype on HIV disease progression
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors: Possible protective effect of infecting HCV genotype on HIV disease progression
چکیده انگلیسی

Background and objectiveHepatitis C virus (HCV) infection is frequent in HIV-positive subjects. We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs).Study designWe studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the follow-up (late progressors; LPs).ResultsHCV coinfection was detected in 19/26 LTNPs and 15/23 LPs. Univariate analysis showed that HIV viral load was associated with disease progression (P = 0.04), and time-to-event analysis indicated that HCV genotype 1 significantly correlated with LTNP status (P = 0.031). At multivariate analysis, HIV viremia at study entry remained independently associated with LTNP status (P = 0.049). When the most represented genotypes (1 and 3a) were considered in the model, genotype 3a infection (P = 0.034) and gender (P = 0.035) emerged as independent variables related to HIV disease progression, whereas HIV viral load disappeared.ConclusionsIn addition to HIV viremia, coinfection with different HCV genotypes and gender may affect LTNP status.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 39, Issue 2, June 2007, Pages 82–86
نویسندگان
, , , , , , , , , , , , ,