Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome

BackgroundThe association between a robust or depressed antibody response and clinical severity of SARS remains unknown.ObjectivesTo study seroconversion and the magnitude of IgG responses in a SARS cohort with different disease severities.Study design and methodA retrospective analysis of all acute and convalescent-phase sera collected from a cohort of laboratory-confirmed SARS cases. Anti-SARS-CoV IgG antibody was detected using indirect immunofluorescence technique and quantified by two-fold serial dilutions. Characteristics of patients who seroconverted “early” (