کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
337283 547490 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MAO A knockout attenuates adrenocortical response to various kinds of stress
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
MAO A knockout attenuates adrenocortical response to various kinds of stress
چکیده انگلیسی

SummaryThe effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on the corticosterone response to restraint, cold, water deprivation-induced, or social acute stress as well as chronic variable stress was studied. It was found that Tg8 mice with genetic MAO A knockout and wild-type C3H/HeJ (C3H) strain showed similar plasma corticosterone resting level. MAO A knockout mice differed from C3H mice by attenuated response to restraint (60 min), cold (4 °C, 60 min), and water deprivation (48 h) as well as to a chronic (15 days) variable stress. No difference between Tg8 and C3H strains in the response to psychosocial stress (encounters for 30 min of six previously isolated mice) has been found. ACTH administration to dexamethasone-pretreated mice produced a similar corticosterone effect in Tg8 and C3H mice, indicating that the decreased stress response in MAO A-deficient mice was due rather to the central mechanisms regulating stress-induced ACTH release than to adrenocortical responsiveness to ACTH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 31, Issue 2, February 2006, Pages 179–186
نویسندگان
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