کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3374627 1219636 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation of Aspergillus species from the airway of lung transplant recipients is associated with excess mortality
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Isolation of Aspergillus species from the airway of lung transplant recipients is associated with excess mortality
چکیده انگلیسی

SummaryBackgroundAspergillus spp. are the leading cause of invasive fungal infection in lung transplant recipients. We investigated the relationship between the isolation of Aspergillus spp. from the respiratory tract of lung transplant recipients and their risk of mortality.MethodsA retrospective, observational cohort study of all patients who received lung allografts between January 1999 and May 2011 at a single UK centre was performed. The time from transplantation to death was analysed using Cox regression models. Isolation of Aspergillus spp. from the respiratory tract was included as a covariate in the Cox regression model.ResultsTwo hundred-thirteen patients were included. The median follow-up time was 5 years during which 102 patients (47.9%) died. Aspergillus was isolated from 74 (34.7%) patients. Twenty patients (27%) had Aspergillus isolated in the first 60 days post-transplant. Forty-one patients (55.4%) in the Aspergillus group and 61 patients (43.9%) in the non-Aspergillus group died during follow-up. A hazard ratio of 2.2 (95% CI 1.5–3.3; P < 0.001) for death following a positive Aspergillus sample was observed.ConclusionIsolation of Aspergillus spp. from patients following lung transplantation is associated with a significant increase in mortality. Novel preventative strategies are required to minimise the impact of Aspergillus in lung transplant recipients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 65, Issue 4, October 2012, Pages 350–356
نویسندگان
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