کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3374769 | 1219647 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis](/preview/png/3374769.png)
SummaryObjectivesT cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) plays an important role in regulating T cell responses and induction of peripheral tolerance. In this study, the association of Tim-3 with active pulmonary tuberculosis (TB) was investigated.MethodsTim-3 expression on CD8 T cells and its influence on production of effector molecules and proliferation of CD8 T cells were examined.ResultsPulmonary TB patients had significantly elevated Tim-3 expression on total CD8 T cells (P < 0.0001) and on antigen-specific CD8 T cells (P = 0.0028) compared with tuberculin-positive healthy controls. The expression of Tim-3 on CD8 T cells was significantly higher in smear/culture-positive TB patients than smear/culture-negative TB patients (P < 0.0001). Tim-3 expressing CD8 T cells had reduced production of IFN-γ, decreased degranulation and lower proliferation in response to Mycobacterium tuberculosis antigen stimulation. Blocking of Tim-3 signaling led to significantly increased production of IFN-γ.ConclusionsThe elevated expression of Tim-3 on CD8 T cells correlates with functional defects of CD8 T cells and disease severity of pulmonary TB.
Journal: Journal of Infection - Volume 62, Issue 4, April 2011, Pages 292–300