کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3374974 | 1219656 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: T-cell changes after a short-term exposure to maraviroc in HIV-infected patients are related to antiviral activity T-cell changes after a short-term exposure to maraviroc in HIV-infected patients are related to antiviral activity](/preview/png/3374974.png)
SummaryObjectivesAnalyze the short-term immunological effect directly attributable to MRV without interference of other drugs.MethodsMRV group included experienced HIV-infected patients undergoing an 8-day MRV monotherapy. A comparison population included naïve HIV-infected patients starting combined antiretroviral therapy (cART group). Absolute CD4+ and CD8+ T-cells and T-lymphocyte subsets were determined at day 0 and 8.ResultsFifty-nine patients who underwent MRV monotherapy and 28 naïve patients were analyzed. Forty-one patients in the MRV group experienced a significant viral load decrease (MRV positive subgroup). Virological response and CD4+ T-cell change were comparable in the MRV positive and cART groups. CD8+ T-cell increase in the MRV positive subgroup showed a trend toward superiority when compared with the cART group. T-lymphocyte subset changes showed a similar profile in the MRV positive and cART groups with a differential effect in the TemRA cells related to MRV. No immunological effect (absolute lymphocyte counts or subsets) was observed in patients without virological response to MRV.ConclusionsMRV produced CD4+ and CD8+ T-cell gains related to antiviral activity and comparable or even superior in terms of CD8+ T-cells to naïve patients starting cART. No immunological effect occurred in subjects without virological response to MRV.
Journal: Journal of Infection - Volume 64, Issue 4, April 2012, Pages 417–423