کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3375332 | 1219672 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Diagnostic performance of T-SPOT.TB for extrapulmonary tuberculosis according to the site of infection Diagnostic performance of T-SPOT.TB for extrapulmonary tuberculosis according to the site of infection](/preview/png/3375332.png)
SummaryBackgroundThe clinical manifestations of extrapulmonary tuberculosis (E-TB) vary according to site of disease, so we tested the hypothesis that IFN-γ producing T-cell responses also vary in parallel. Therefore we conducted a prospective, blinded, observational study to evaluate the diagnostic performance of blood T-SPOT.TB according to the various sites of E-TB.MethodsFrom April 2008 to August 2010, all patients with suspected E-TB were enrolled at a tertiary hospital in an intermediate TB-burden country. Final diagnosis in patients with suspected E-TB was classified by clinical category.ResultsA total of 368 patients with suspected E-TB were enrolled; 196 (53%) were classified as having TB, including 119 (32%) with confirmed TB, 34 (9%) probable TB, and 43 (12%) possible TB; the remaining 172 (47%) were classified as not having TB. After excluding patients with possible TB, the T-SPOT.TB was more sensitive in patients with chronic forms of E-TB such as lymph node or osteoarticular TB (93%, 95% CI 83%–97%) than in patients with acute forms of E-TB such as TB meningitis or miliary TB (79%, 95% CI 66%–87%, P = 0.03).ConclusionsThe diagnostic performance of the blood T-SPOT.TB differs among patients with various clinical manifestations of E-TB.
Journal: Journal of Infection - Volume 63, Issue 5, November 2011, Pages 362–369