کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3375408 1219678 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Incidence and clinical impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Incidence and clinical impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies
چکیده انگلیسی

SummaryObjectivesTo identify risk factors for mortality in patients suffering from hematological malignancies with concurrent bacteremia caused by Escherichia coli. Particular attention was focused on defining the impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance by the bacterial isolates on mortality.Materials and methodsA retrospective eight-year cohort study design was employed. The outcome measured was death within 30 days of the first positive blood culture. Survivor and non-survivor subgroups were compared to identify predictors of mortality.ResultsA total of 62 episodes of bacteremia caused by E. coli were analyzed. The overall incidences of ESBL production and fluoroquinolone resistance were 41.9% and 62.9%, respectively. The overall 30-day mortality rate was 20.9% (13/62). In a multivariate analysis, significant predictors of mortality were inadequate initial antimicrobial therapy (OR = 14.96, 95% CI 1.95–114.51; P = 0.009), infection caused by ESBL-producing isolates (OR = 8.84, 95% CI 1.48–52.91; P = 0.01), and prolonged neutropenia (OR = 8.10, 95% CI 1.29–50.57; P = 0.02).ConclusionsSound knowledge of the local distribution of pathogens and their susceptibility patterns and prompt initiation of effective antimicrobial treatment are essential in patients suffering from hematological malignancies with BSIs caused by E. coli.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 58, Issue 4, April 2009, Pages 299–307
نویسندگان
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