کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3375431 1219680 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The inflammasome regulatory pathway and infections: Role in pathophysiology and clinical implications
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
The inflammasome regulatory pathway and infections: Role in pathophysiology and clinical implications
چکیده انگلیسی

SummaryThe innate immune system serves to generate immediate host defenses against pathogens. Advance in the mechanism of innate immunity has provided new insights into host-pathogen microbial interactions. The cytosolic multi-protein complex called the inflammasome, which regulates the caspase-1 dependent processing of inflammatory cytokines IL-1β and IL-18, is critical for the innate defense against pathogens. We summarize the current knowledge regarding the regulatory functions of the inflammasome in the pathogenesis of infections by various microbes (e.g., bacteria, fungi, viruses, and protozoa), and discuss its potential application in a clinical setting. Understanding of the unique role of the inflammasome signaling pathway in initiating and regulating inflammation is pivotal for the development of innovative approaches to optimize management of these infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 62, Issue 2, February 2011, Pages 119–129
نویسندگان
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