Expression and regulation of chemokines in mycobacterial infection

SummaryChemokines are the key molecules that recruit immune cells by chemotaxis and act in leukocyte activation during mycobacterial diseases. Currently, tuberculosis is a leading infectious disease affecting millions of people worldwide. The purpose of this review is to describe a series of recent scientific evidence concerning to the protective role of some members of the CC- and the CXC chemokine subfamilies for the control of mycobacterial infection. The discussion will (1) highlight the effectiveness of some chemokines as potent immunoprophylactic tool for controlling the mycobacterial establishment within the host, (2) describe recent work on the relevance of cellular signaling pathways by which mycobacterial antigens mediate chemokine induction, and (3) summarize current progress in the understanding of the potential use of chemokines as potent adjuvants in antimycobacterial immune responses.