کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3375927 | 1219700 | 2007 | 4 صفحه PDF | دانلود رایگان |

SummaryShigellosis is an important cause of acute diarrheal disease and multidrug-resistant phenotype has been reported in S. sonnei. In this study, we investigate the resistance and identify extended-spectrum β-lactamases (ESBLs) gene in 37 S. sonnei isolates by agar dilution procedure and the modified three-dimensional test, respectively. The bla genes of ESBL-producing isolates were detected by polymerase chain reaction (PCR) and sequencing. More than 50% of these strains were resistant to tetracycline, sulfamethoxazole-trimethoprim, ampicillin, ampicillin-sulbactam, or gentamicin. However, they were still susceptible to third generation cephalosporins, fluoroquinolones, and chloramphenicol. A total of 8.1% (3/37) of the isolates with intermediate susceptibility to ceftriaxone and cefotaxime were ESBL-producers, which produced CTX-M-14 ESBLs and TEM-1 β-lactamases. This is the first report of CTX-M-14 in S. sonnei isolates from China and it is important to closely monitor such strains.
Journal: Journal of Infection - Volume 55, Issue 5, November 2007, Pages e125–e128