کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3376457 1219733 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis
چکیده انگلیسی

SummaryObjectiveProphylactic strategies against invasive pulmonary aspergillosis are often limited by drug interactions and toxicities. Targeted airway delivery of antifungals to the lungs may avoid these pitfalls. We evaluated the effectiveness of an aerosolized nanostructured formulation of itraconazole produced by spray freezing into liquid (SFL) as prophylaxis against invasive pulmonary aspergillosis caused by A. fumigatus.MethodsImmunocompromised Balb/C mice received either itraconazole by oral gavage (Sporanox Oral Liquid [SOL] 30 mg/kg TID) or by aerosolization (SFL 30 mg/kg via 20 min aerosolizations, or control, BID). Dosing began 2 days prior to pulmonary inoculation with A. fumigatus and continued for 7 days post-inoculation. Changes in lung histopathology were also assessed. In the survival arm, mice were monitored over a 5 day period following discontinuation of therapy and survival was assessed by Kaplan–Meier analysis.ResultsSFL survival (35%) was greater compared to control (10%; p = 0.03) and SOL (0%; p = 0.02). Histopathology demonstrated severe invasive disease involving vessels and small airways in control and SOL animals. SFL animals demonstrated colonization with some invasion predominately of large airways.ConclusionsProphylactic aerosolization of nanostructured SFL significantly improved survival and limited invasive disease of small airways due to A. fumigatus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection - Volume 55, Issue 1, July 2007, Pages 68–74
نویسندگان
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