کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3377433 1219984 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system
چکیده انگلیسی

We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection and Chemotherapy - Volume 15, Issue 2, 2009, Pages 113-117