کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3381546 | 1220262 | 2007 | 10 صفحه PDF | دانلود رایگان |

SummaryObjectiveThe aim of this study was to follow, over a 4½-month period, the medial tibia cartilage thickness on a meniscectomy (MNX) guinea pig osteoarthritis (OA) model and to compare with control animals, using three-dimensional high-resolution magnetic resonance imaging (3D HR-MRI).MethodsMRI experimentations were performed in vivo at 7 T on guinea pig knee joints. 3D HR-MR images were acquired in 60 controls (SHAM) and 45 osteoarthritic animals (MNX) at four time-points (15, 45, 90 and 135 days) after surgery. Medial tibial cartilage thickness was measured from MRI images using in-house dedicated 3D software followed by a statistical analysis. At each time-point 15 SHAM and 15 MNX animals were sacrificed for histomorphometric assessments.ResultsNo significant difference of mean cartilage thickness between the groups was found at early stage (D45) using MRI; however, significant differences were found between the groups at D90 (P < 0.001) and D135 (P < 0.001). Histomorphometry data confirmed the pathological status of the animals and was well correlated with MRI at D15 (r = 0.79, P < 0.01), D45 (r = 0.67, P < 0.01), and D135 (r = 0.39, P < 0.05) for SHAM, and at D45 (r = 0.63, P < 0.01), and D135 (r = 0.81, P < 0.01) for MNX.ConclusionMedial tibial cartilage measurement based on HR-MR images enables the monitoring of longitudinal cartilage thickness changes. This technique showed significant differences between SHAM and MNX as from D90 after surgery. It could be used as a noninvasive and reproducible tool to monitor therapeutic response in this OA model.
Journal: Osteoarthritis and Cartilage - Volume 15, Issue 6, June 2007, Pages 656–665