کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3392915 1221301 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: A diagnostic challenge?
ترجمه فارسی عنوان
تشخیص بیماری های گرمسیری از بیماری سلیاک در مسافران با اسهال مزمن: یک چالش تشخیصی؟
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

SummaryBackgroundWithin the present era of worldwide travel, it is important for all clinicians to consider the possibility of tropical sprue (TS) in returning patients with persistent diarrhoea after travel. The symptoms and histologic findings of TS can resemble but also be confused with celiac disease (CD).Material and methodPatients at our institute diagnosed with CD or TS in the period January 2000–December 2010 were eligible for inclusion. Of all patients, demographic, clinical, laboratory and endoscopy data on admission and in follow-up were collected retrospectively.Results28 CD and 7 TS patients were included. There were no differences in baseline clinical characteristics, duration of stay in a tropical region or in laboratory findings on admission. However, in the majority of CD patients antibodies against endomysium (EMA) or tissue transglutaminase (tTG) were present at presentation but absent in all TS patients at presentation.ConclusionsIn returning travellers with persistent diarrhoea, a diagnosis of CD is unlikely in case of absence of anti-EMA or anti-tTG antibodies but conversely increases the likelihood of TS. This distinct immunoserological profile may be of help in selecting the optimal treatment in returning travelers with chronic diarrhoea after staying in a tropical region.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Travel Medicine and Infectious Disease - Volume 12, Issue 4, July–August 2014, Pages 401–405
نویسندگان
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