کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3393418 1221340 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cutaneous leishmaniasis treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Cutaneous leishmaniasis treatment
چکیده انگلیسی

SummaryThe causative species of cutaneous leishmaniasis determines the clinical features and courses, and treatments. Intralesional or systemic antimonials are the gold standard for the treatment of these diseases. However, as for visceral leishmaniasis, other therapeutic options appear promising. Paromomycin ointments are effective in Leishmania major, L. tropica, L. mexicana, and L. panamensis lesions. In L. braziliensis localized leishmaniasis, both paromomycin and imiquimod may be topically applied. Oral fluconazole and zinc sulfate are useful in L. major. Oral azithromycin, effective in vitro and in mice, needs further investigation in human leishmaniasis. On the contrary, data with oral itraconazole are disappointing. Oral miltefosine, which is very effective in visceral leishmaniasis caused by L. donovani, appears ineffective in L. major and L. braziliensis infections. Intramuscular pentamidine is required for L. guyanensis cutaneous leishmaniasis, for which systemic antimony is not effective. Liposomal amphotericin B could be an alternative to antimony in south American cutaneous leishmaniasis with mucosal involvement (especially L. braziliensis and L. guyanensis infections).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Travel Medicine and Infectious Disease - Volume 5, Issue 3, May 2007, Pages 150–158
نویسندگان
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