کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3399987 | 1593064 | 2015 | 7 صفحه PDF | دانلود رایگان |
BackgroundTumor markers were used in malignant pleural effusion with negative cytology.Aim of the workThe aim was to assess the value of serum and pleural levels of cyfra 21-1 (fragment of cytokeratin 19) and carcinoembryonic antigen (CEA) in the diagnosis of malignant pleural effusion.Patients and methodsThis study was conducted on 48 patients divided into group I (benign effusion) and group II (malignant effusion). Chest X-ray P.A view, pleural fluid analysis and measurement of serum and pleural levels of CEA and cyfra 21-1 were done.ResultsSerum and pleural levels of cyfra 21-1 and CEA were significantly increased in the malignant group and compared to other groups. Sensitivities of cyfra 21-1 and CEA in serum were 90.4 and 90.5 and in pleural fluid were 94.7 and 92.6, the specificities of cyfra 21-1 and CEA in serum were 86.9 and 83.5 and in pleural fluid were 89.3 and 85.8 but sensitivity of both cyfra 21-1 and CEA in serum and pleural fluid was 100 and specificities in serum and pleural fluid were 92.86 and 96.43.ConclusionMeasurement of cyfra 21-1 and CEA in serum and pleural fluid is helpful in differentiation between benign and malignant pleural effusions.
Journal: Egyptian Journal of Chest Diseases and Tuberculosis - Volume 64, Issue 2, April 2015, Pages 411–417