کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3400100 1593065 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Malignant pleural effusion biomarkers as predictor for chemical pleurodesis success
ترجمه فارسی عنوان
بیومارکرهای پلورال افیوژن بدخیم به عنوان پیش بینی کننده موفقیت شیمیائی پلورودیز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
چکیده انگلیسی

Background42–77% of exudative pleural effusions are due to malignant diseases (Marel et al., 1993) [1]. This study aimed to evaluate the value of biochemical parameters of the pleural aspirate in predicting success of chemical pleurodesis in adult patients with malignant pleural effusion.Patients and methodsThis prospective study included 30 adult patients with malignant pleural effusion diagnosed by clinical examination, Chest CT scanning and closed pleurocentesis. Patient ages were mean of 60.4 ± 7.8 years, multiple sessions of closed pleurocentesis were carried out followed by insertion of an intercostal tube. The pleural aspirate was then sent for chemical analysis to detect Glucose, pH, and LDH. Pleurodesis was then done either by using Tetracycline (group A), or Bleomycin (group B). All patients were then followed up for success of the pleurodesis process within one month.ResultsWithin one month of follow-up, rates of clinical response to treatment in group A (Tetracycline) were successful in 40%; versus group B (73.3%). Complete response (CR) occurred in group A cases (20%); versus 33.3% in group B; whereas partial response (PR) occurred in 3 cases of group A; versus 6 cases of group B; and treatment failure (TF) occurred in 9 of group A cases versus 4 of group B cases. None of our patients died. Morbidity occurred in the form of mild-to-moderate.The success of the pleurodesis was closely-associated with higher glucose and pH levels together with a low LDH level in the pleural fluid.ConclusionThe success of pleurodesis is usually higher when the pleural fluid pH and glucose levels are high & the LDH level is low in MPE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Chest Diseases and Tuberculosis - Volume 64, Issue 1, January 2015, Pages 153–160
نویسندگان
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