کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3400146 1593069 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insulin resistance in obstructive sleep apnea
ترجمه فارسی عنوان
مقاومت به انسولین در آپنه انسدادی خواب
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
چکیده انگلیسی

IntroductionOSA is a common condition that is characterized by intermittent and recurrent pauses in respiration results in multiple cycles of hypoxia/reoxygenation with an increased production of reactive oxygen species (ROS).Aim of workIs to assess serum insulin level and insulin resistance in obese patients with and without OSA.Subjects and methodsStudy was performed on 51 obese subjects who had been referred to the Chest Department of Kasr Alaini Hospital with clinical suspicion of OSA in order to perform polysomnography. They were classified into two groups; cases: consist of 33 obese patients who were diagnosed as obstructive sleep apnea (OSA) and controls: consist of 18 obese subjects, without OSA as a control group. The two groups were subjected to polysomnographic study, serum insulin by ELISA and assessment of insulin resistance by calculation of HOMA index.ResultsThere was statistically highly significant increase in Epworth sleepiness scale (ESS) among cases compared to controls. As regards the polysomnographic data, there was statistically highly significant increase in AHI, desaturation index and duration of desaturation <90% among cases compared to control subjects. Regarding minimal O2 sat% and average O2 sat% were lower in cases than in the control subjects and this reduction was statistically significant. There was statistically highly significant increase in serum insulin, HOMA index among cases as compared to controls.ConclusionInsulin resistance in OSA is related to sleep associated hypoxemia and hypoxic stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Chest Diseases and Tuberculosis - Volume 63, Issue 1, January 2014, Pages 133–139
نویسندگان
, , , , ,