کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3400171 1593067 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional and histological effects of inhaled magnesium alone or associated to fluoride: An experimental study in rats
ترجمه فارسی عنوان
اثرات کارکردی و بافت شناسی منیزیم استنشاقی به تنهایی یا همراه با فلوراید: یک مطالعه تجربی در موش صحرایی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
چکیده انگلیسی

The study was carried out to investigate the effects of inhaled Mg alone and associated with F in the treatment of bronchial hyperresponsiveness. 43 male Wistar rats were randomly divided into four groups and exposed to inhaled NaCl 0.9%, MeCh, MgSO4 and MgF2. Pulmonary changes were assessed by means of functional tests and quantitative histological examination of lungs and trachea. Results revealed that delivery of inhaled Mg associated with F led to a significant decrease of total lung resistance better than inhaled Mg alone (p < 0.05). Histological examinations illustrated that inhaled Mg associated with F markedly suppressed muscular hypertrophy (p = 0.034) and bronchoconstriction (p = 0.006) in MeCh treated rats better than inhaled Mg alone. No histological changes were found in the trachea. This study showed that inhaled Mg associated with F attenuated the main principle of the central components of changes in MeCh provoked experimental asthma better than inhaled Mg alone, potentially providing a new therapeutic approach against asthma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Chest Diseases and Tuberculosis - Volume 63, Issue 3, July 2014, Pages 535–540
نویسندگان
, , , , , ,