کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3400197 1593067 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CRP evaluation in non-small cell lung cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
پیش نمایش صفحه اول مقاله
CRP evaluation in non-small cell lung cancer
چکیده انگلیسی

BackgroundCRP is an inflammatory mediator that is shown to be elevated in different inflammatory and malignant conditions, the aim of the study to see whether the elevated serum CRP is correlated with the advanced stages and increased tumor size of NSCLC after exclusion of patients with high CRP due to infection.Materials and methods71 patients with proved NSCLC and 25 healthy control volunteers were selected for the study, serum CRP and PCT were analyzed, results of CRP in patients with NSCLC were compared with the control group, and subgroups were made according to different clinical variables as subtypes of lung cancer, tumor staging and tumor size.ResultsThe serum CRP level was significantly higher in patients with NSCLC compared to the control group 114.2 ± 60.1 mg/ml vs. 13.4 ± 8.6 mg/ml) with p value <0.001, no significant difference was recorded in PCT level (p > 0.05), there was no significant difference between NSCLC subtypes (p > 0.05), there was a positive correlation between CRP level and tumor size (p < 0.01), TNM tumor staging (p < 0.01).ConclusionCRP is an inflammatory biomarker that is shown to be elevated in NSCLC and its elevation is correlated with the tumor size and tumor staging but not to subtypes of NSCLC, it may point to poor outcome and poorer prognosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Egyptian Journal of Chest Diseases and Tuberculosis - Volume 63, Issue 3, July 2014, Pages 717–722
نویسندگان
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