کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3405419 | 1223382 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Une brève histoire des résistances plasmidiques aux quinolones
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماری های عفونی
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چکیده انگلیسی
For many years, quinolone resistances was only known as a chromosomal resistance until the qnrA gene description. Plasmid-mediated quinolone resistances (PMQR) can be classified according to their function: protection of the Gyrase by Qnr, drug inactivation by AAC(6â²)-Ib-cr and increased efflux by QepA, OqxAB, QacBIII and the multidrug transporter carried by the plasmid pRSB101. Their role and mechanistic are not totally deciphered. PMQR confers low-level resistance and fluoroquinolone MICs remain below the susceptibility breakpoints. However, recent studies have reported that Qnr decreased the bactericidal activity of ciprofloxacin in murine models of pneumonia and urinary tract infections. These findings could lead to propose to use carefully fluoroquinolones to treat infection due to a strain harbouring PMQR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal des Anti-infectieux - Volume 15, Issue 1, March 2012, Pages 1-8
Journal: Journal des Anti-infectieux - Volume 15, Issue 1, March 2012, Pages 1-8
نویسندگان
T. Guillard, E. Cambau,