کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3444343 1595276 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systemic markers of oxidative status and colorectal adenomatous polyps
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Systemic markers of oxidative status and colorectal adenomatous polyps
چکیده انگلیسی

PurposeOxidative damage has been implicated in carcinogenesis. We hypothesized that elevated systemic oxidative status would be associated with later occurrence of colorectal adenomatous polyps, a precursor of colorectal cancer.MethodsWe examined the prospective association between four systemic markers of oxidative status and colorectal adenomatous polyps within a nondiabetic subcohort of the Insulin Resistance Atherosclerosis Study (n = 425). Urine samples were collected from 1992 to 1994 and colorectal adenomas prevalence were assessed in 2002 to 2004. Oxidative status markers were assessed, which included four F2-isoprostanes (F2-IsoPs) from the classes III and IV: iPF2α-III, 2,3-dinor-iPF2α-III (a metabolite of iPF2α-III), iPF2α-VI, and 8,12-iso-iPF2α-VI. All biomarkers were quantified using liquid chromatography–tandem mass spectrometry. Prospective associations were assessed using multivariate logistic regression analysis.ResultsThe adjusted odds ratio (OR) (95% confidence interval [CI]) for occurrence of colorectal adenomatous polyps and scaled to 1 SD of F2-IsoP distribution were 1.16 (95% CI, 0.88–1.50), 0.88 (95% CI, 0.63–1.17), 1.04 (95% CI, 0.80–1.34), and 1.16 (95% CI, 0.90–1.48) for iPF2α-III, iPF2α-VI, 8,12-iso-iPF2α-VI, and 2,3-dinor-iPF2α-III, respectively.ConclusionsThe lack of association between F2-IsoPs and adenomatous polyps does not support the hypothesis that elevated oxidative status is associated with colorectal adenomatous polyp occurrence during a 10-year period of follow-up.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 22, Issue 8, August 2012, Pages 587–591
نویسندگان
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