کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3446806 | 1595493 | 2011 | 7 صفحه PDF | دانلود رایگان |

Background and AimsVariants in the transcription factor 7-like 2 (TCF7L2) gene are consistently associated with type 2 diabetes in adults, but the association of TCF7L2 with weight-related traits and body fat in humans is unclear. The aim of this study was to determine the relationship between the TCF7L2 gene (rs12255372) and obese phenotype in Mexican school-age children.MethodsThe study was performed in schools in Mexico City; 186 obese and 194 control children were studied. Fasting insulin and glucose, total cholesterol, LDL-C, HDL-C and triglycerides concentration were determined. The variant rs12255372 of the TCF7L2 gene was genotyped. We used age- and sex-adjusted linear models to test for association with metabolic measurements with this variant.ResultsGenotype of the TCF7L2 rs12255372 gene was associated with lower fasting plasma glucose (p = 0.001) and lower homeostasis model assessment of insulin resistance (HOMA-R; p = 0.001) in nonobese children. Heterozygous carriers for this variant were more prevalent in lean children (32.5%) than in the obese group (23.7%), which resulted in a strong protective effect for the normal weight condition (OR = 0.56, 0.32–0.97).ConclusionsTCF7L2 rs12255372 polymorphism protects Mexican children from obesity. Further research in other large, population-based studies is needed to replicate these findings.
Journal: Archives of Medical Research - Volume 42, Issue 6, August 2011, Pages 495–501